ea0015oc12 | Reproduction | SFEBES2008
Cadman Steven
, Philp Gregory
, Kim Soo-Hyun
, Bouloux Pierre-Marc
, Mason Ivor
Kallmanns syndrome (KS) is proposed to result from disrupted migration of both olfactory sensory axons and hypothalamic gonadotrophin-releasing hormone (GnRH1) neurons during embryogenesis. KAL1 (encoding anosmin-1) and KAL2 (encoding the fibroblast growth factor receptor 1, FGFR1) are responsible for approximately 20% of KS cases, and in an ex vivo system it has been reported that anosmin-1 enhances FGFR1 signalling in a ligand (FGF)- and heparan su...